The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer

  • Yoones Baziyar Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvedasht, Iran
  • Mohammad Amin Edalatmanesh Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  • Seyed Ali Hosseini Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvedasht, Iran
  • Abdossaleh Zar Department of Physical Education and Sport Science, Jahrom University, P.O. Box 74135-111, Jahrom, Iran

Abstract

Background: In the present study, the effects of endurance training and chronic administration of Gallic acid (GA) on hippocampal level of brain-derived neurotrophic factor (BDNF) and tumor necrosis factor alpha (TNF-α) in trimethyltin (TMT)-induced hippocampal degeneration as a model of Alzheimer’s disease were investigated.

Methods: 70 male Sprague-Dawley rats were selected and randomly assigned to 7 groups: 1.control, 2.TMT, 3.TMT+GA50, 4.TMT+GA100, 5.TMT+Ex, 6.TMT+Ex+GA50, 7.TMT+Ex+GA100. For induction of Alzheimer's disease, the rats in groups 2-7 were injected with single dose of TMT (8 mg/kg), intra-peritonealy (i.p.). Rats in the groups 5, 6 and 7 carried out an 8-week exercise program on a motorized treadmill (15-20 m/min, 0% inclination for 15-30 min/day, 5 days/week).  In addition, the groups 3 and 6 were treated by 50 mg /kg and groups 4 and 7 are administered 100 mg/ kg of Gallic acid for 2 weeks. Then, the hippocampal level of BDNF and TNF-α was performed for all groups by Elisa.

 Results: The findings of present study showed that the hippocampal level of BDNF in all test groups are significantly higher than TMT group (p≤0.05) and the hippocampal level of TNF-a in all test groups is significantly less than the TMT group (p≤0.05).

Conclusion: Endurance exercises training, chronic administration of GA and co-treatment with training and GA consumption specially, having sufficient neurotrophic and immune modulator effects in male rats with Alzheimer.

 Keywords: Alzheimer’s disease, Endurance training, Gallic acid, BDNF, TNF-a, hippocampus 

Downloads

Download data is not yet available.
Published
2017-01-23
How to Cite
Baziyar, Y., Edalatmanesh, M. A., Hosseini, S. A., & Zar, A. (2017). The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer. International Journal of Applied Exercise Physiology, 5(4), 45-54. Retrieved from http://www.ijaep.com/index.php/IJAE/article/view/109
Section
Sport Science