Assessment Of Physiological Cardio respiratory Parameters During Sub maximal Exercise On Acute Exposure To Normobaric Hypoxia In Healthy Young Males

  • Bipin K Shrestha Nepalese Army Institute of Health Sciences, Sanobharyang, Nepal
  • Surinder Pal Singh Armed Forces Medical College, Pune, India


To estimate changes in SBP, DBP, HR, RR and Lactate Level at Near Sea Level (NSL) and at Simulated altitude (3000meters) at rest and during sub-maximal exercise.Mean Resting values at NSL vs. Hypoxic Chamber were: SBP (1276vs1325mmHg), DBP (703vs786mmHg), HR (725vs806bpm), RR (254vs293/min) and LL (2.10.35vs2.50.42mmol/l). Similarly, mean values at the end of exercise were: SBP (1529vs16913mmHg), DBP (836vs926mmHg), HR (13412vs1557bpm), RR (356vs516/min) and LL (7.110.89vs8.011.03mmol/l).  A significant difference exists in mean resting values of SBP, DBP, HR and RR at NSL and on acute exposure to Normobaric Hypoxia. Sub-maximal exercise in hypoxic conditions appears to depend more on anaerobic metabolism and results in greater sympathetic activity.
Keywords: Cardiorespiratory parameters, Normobaric hypoxia, Sub-maximal exercise, Near Sea Level


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1. Torricelli E. Letter of Torricelli to Michelangelo Ricci. 1644. In: West JB, ed. High Altitude Physiology. Stroudsburg, PA: Hutchinson Ross; 1981:60-3.
2. Bartsh P, B. General introduction to altitude adaptation and mountain sickness. Scand J Med Sci Sports 2008: 18; 1-10.
3. Guyton A, Hall E. Sports Physiology. In: Guyton and Hall Textbook Of Medical Physiology. 12th ed. Philadelphia: Elsevier Saunders, 2011; 1031-1041.
4. Ciulla M, Cortiana M. Effects of simulated altitude (normobaric hypoxia) on cardiorespiratory parameters and circulating endothelial precursors in healthy subjects. Respiratory Research 2007: 8:58 doi: 10.1186/1465-9921-8-58
5. Rahn H, Otis AB. Man’s respiratory response during and after acclimatization to high altitude. Am J Physiol. 1949; 157:445-62.
6. Friedmann B, Frese F, Menold E,?Bartsch P. Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia. Int J Sports Med 2005; 26:531–536
7. Koistinen P, Takala T, Martikkala V, Leppa luoto J. Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia. Int J Sports Med 1995: 16: 78–81.
8. Dempsey JA, Forster HV. Mediation of ventilatory adaptations. Physiol Rev.62:262-346,1982.
9. Moore LG, Niermeyer S, Zamudio S. Human adaptation to high altitude: regional and life-cycle perspectives. Am J Phys Anthropol. 1998; Suppl 27:25-64. [PMID: 9881522]?2.
10. Fulco CS, Cymerman A. Maximal and submaximal exercise performance at altitude. Aviat Space Environ Med 1998: 69: 793–801.
11. Boushel R, Calbet J-AL, Ra degran G, Søndergaard MS, Wagner PD, Saltin B. Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 2001: 104: 1785–1791.
12. Favret F, Richalet J-P. Exercise and hypoxia: the role of the autonomic nervous system. Respir Neurobiol Physiol 2007: 158: 280–286.
13. Grover RF, Weil JV, Reeves JT. Cardiovascular adaptation to exercise at high altitude. Exerc Sport Sci Rev 1986: 14: 269–302.
14. Dill DB, Edwards HT, Folling A, Oberg SA, Pappenheimer AM, Tabott JH. Adaptations of the organism to changes in oxygen pressure. J Physiol 1931: 71: 47–63.
15. Reeves JT, Groves BM, Sutton JR, Wagner PD, Cymerman A, Malconian MK, Rock PB, Young PM, Houston CS. Operation Everest II: preservation of cardiac function at extreme altitude. J Appl Physiol. 1987; 63:531–539.
16. Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001; 345: 107-14. [PMID: 11450659]
17. Sarkar S, Banerjee PK, Selvamurthy W: High altitude hypoxia: an intricate interplay of oxygen responsive macroevents and micromolecules. Mol Cell Biochem 2003; 253:287-305.
18. Guyenet PG: Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 2000; 121:147-62.
19. Arias-Stella J, Kruger H. Pathology of high altitude pulmonary edema. Arch Pathol.76: 147,1967.
20. Houston CS. Acute pulmonary edema of high altitude. N Engl J Med. 1960; 263:478-80. [PMID: 14403413]
21. Hultgren HN, Lopez CE, Lundberg E, Miller H. Physiologic studies of pulmonary edema at high altitude. Circulation. 1964; 29:393-408. [PMID: 14131411]
22. Chapman RW, Santiago TV, Edelman NH. Brain hypoxia and control of breathing: neuromechanical control. J Appl Physio
How to Cite
K Shrestha, B., & Pal Singh, S. (2016). Assessment Of Physiological Cardio respiratory Parameters During Sub maximal Exercise On Acute Exposure To Normobaric Hypoxia In Healthy Young Males. International Journal of Applied Exercise Physiology, 5(2), 27-36.
Applied Exercise Physiology